Chronic non-bacterial osteomyelitis and autoinflammatory bone diseases
نویسندگان
چکیده
منابع مشابه
Chronic non-bacterial osteomyelitis in children.
BACKGROUND Chronic recurrent multifocal osteomyelitis (CRMO) in children is a chronic non-suppurative inflammation involving multiple sites. Some children affected by chronic non-bacterial osteomyelitis (CNO) do not have multiple lesions or a recurrent course. OBJECTIVE To characterise the long term outcome of children with the full spectrum of CNO. METHODS 30 children diagnosed with CNO we...
متن کاملUnifocal and multifocal chronic non-bacterial osteomyelitis (CNO) in children
Methods We retrospectively evaluated patients with sterile bone inflammation, lasting longer than 6 month, referred to two tertiary care pediatric rheumatology units. Information on family history, clinical features at disease onset and course, laboratory and outcome were collected. A comparison between unifocal (UF-CNO) and multifocal course (MF-CNO), based on bone scintiscan result, was perfo...
متن کاملAutoinflammatory bone disorders with special focus on chronic recurrent multifocal osteomyelitis (CRMO)
Sterile bone inflammation is the hallmark of autoinflammatory bone disorders, including chronic nonbacterial osteomyelitis (CNO) with its most severe form chronic recurrent multifocal osteomyelitis (CRMO). Autoinflammatory osteopathies are the result of a dysregulated innate immune system, resulting in immune cell infiltration of the bone and subsequent osteoclast differentiation and activation...
متن کاملImmunopathogenesis of granulomas in chronic autoinflammatory diseases
Granulomas are clusters of immune cells. These structures can be formed in reaction to infection and display signs of necrosis, such as in tuberculosis. Alternatively, in several immune disorders, such as sarcoidosis, Crohn's disease and common variable immunodeficiency, non-caseating granulomas are formed without an obvious infectious trigger. Despite advances in our understanding of the human...
متن کاملNon-bacterial chronic recurrent osteomyelitis of the clavicle.
ABSTRACT This report details the case of a 12-year-old girl with a painful, progressive swelling of the medial portion of the clavicle with no history of trauma or other constitutional symptoms. All laboratory investigations were normal except for an elevated erythrocyte sedimentation rate (ESR). Initial plain radiographs showed a destructive lesion with magnetic resonance imaging showing featu...
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ژورنال
عنوان ژورنال: Clinical Immunology
سال: 2020
ISSN: 1521-6616
DOI: 10.1016/j.clim.2020.108458